Antidiabetic Agents

At Hi Pharm, our main concern has always been to contribute to the treatment of chronic diseases and raise the quality of life, so it was necessary to provide one of the best anti-diabetes in the Egyptian market.

Diabetes mellitus is a chronic, lifelong condition that affects your body’s ability to use the energy found in food, and if you neglect the treatment you may suffer from serious complications.

What do you need in an Antidiabetic agent?

Effective oral hypoglycemic agents act as insulin sensitizers.
High safety profile… low incidence of side effects.
No hypoglycemia in monotherapy… as no direct effect on the pancreas.
Single oral daily dose…. better patient compliance.
Reduce insulin resistance, improve glycemic control & reduce HbA1C.

We can tell that all these advantages are gathered in our precious antidiabetic agent Pioglitazone, which is one of the Thiazolidinediones that can treat diabetes and insulin resistance by:

Increase the number & activity of GLUT4.
Decrease gluconeogenesis.
Increase lipoprotein lipase.
Increase fatty acid transport protein.
Decrease triglyceride.
Decrease free fatty acids.

Pioglitazone and its Extra Value:

That marvelous molecule is not only treating diabetes but also has a great role in NAFLD (nonalcoholic fatty liver disease) treatment as it can:

Pioglitazone was shown to improve NAFLD in some human studies, Pioglitazone also decreases fasting and postprandial glucose levels by improving insulin sensitivity in type 2 diabetes mellitus and is currently used as an antidiabetic medication.
Pioglitazone acts by binding to the peroxisome proliferator-activated receptor gamma (PPAR), a member of the nuclear receptor superfamily that plays a key role in glucose regulation and lipid metabolism.
Pioglitazone is extensively metabolized by hydroxylation and oxidation in the liver to form at least four primary metabolites (M-I, M-II, M-IV, and M-V) and two secondary metabolites (M-III and M-VI). Pharmacologically active M-IV and M-III are the main metabolites found in the human serum.
Pioglitazone is metabolized by multiple cytochrome P450 (CYP) enzymes, mainly CYP2C8, CYP3A4, and CYP2C9, which are regulated by the xenobiotic receptor constitutive androstane receptor (CAR). CAR activity may affect the metabolism of pioglitazone and the effects of pioglitazone may vary according to the degree of metabolism.
Pioglitazone is used for the treatment of NAFLD by improving insulin sensitivity & obesity accompanied by insulin resistance, aminotransferases, steatosis, inflammation, and ballooning in patients with NASH and prediabetes or T2DM.

Our high-quality Pioglitazone of Hi Pharm, has a great contribution in the treatment of Polycystic Ovary Syndrome (POS), as it can:

lower insulin resistance in PCOS. It may also help reduce androgen levels, slow hair growth, and help you ovulate more regularly.
It was found that Pioglitazone may be a new alternative for use in women with PCOS, providing more metabolic and reproductive benefits and possibly protection from developing diabetes and cardiovascular problems

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